Norovirus vaccine pill shows promise against ‘winter vomiting’ bug
An artist’s impression of the norovirus Science Photo Library/Alamy An early trial of a norovirus vaccine pill has shown promise at protecting against the notorious “winter vomiting” bug, with researchers saying it could potentially be available for use in a few years. The virus is highly contagious, infecting the stomach and intestines and causing vomiting and diarrhoea. Most people recover within a few days, but very young and older people are especially at risk of ending up in hospital, with significant healthcare costs. “Just in the US alone, it’s a 10 billion-[dollar]-a-year problem,” says Sean Tucker at biotech company Vaxart in San Francisco, California. This has spurred scientists to develop a vaccine, but so far, efforts have failed. That is partly because prior attempts have focused on developing injectable vaccines, which are less good at generating protective antibodies in the intestine, where the virus replicates, says Tucker. To address this, Tucker and his colleagues previously developed an oral norovirus vaccine that delivers a protein from the GI.1 norovirus variant into the intestine. An initial trial …