Revolutionary nano-chip quickly detects earliest sign of heart attack
Surface-enhanced Raman spectroscopy (SERS) is revolutionizing biomedical diagnostics and therapeutics, enabling breakthroughs in biopharmaceuticals, antimicrobial resistance detection, forensic science, and homeland security. With its unique ability to detect molecular fingerprints with single-molecule sensitivity, SERS offers unparalleled potential. However, translating this method into reliable clinical tools faces significant hurdles—chiefly the reliance on electric fields for signal enhancement and unpredictable intensity fluctuations. Traditionally, SERS enhancement depends on electromagnetic fields, particularly electric fields (E-fields). While effective, the magnetic field (H-field) component remains underutilized due to the limited magnetic permeability of metals at optical frequencies. This omission underscores a missed opportunity to fully exploit electromagnetic mechanisms in SERS. Addressing this gap requires innovative solutions, such as plasmonic substrates that activate both E- and H-fields. Recent advances in photonic metamaterials present a promising path forward. Published in the journal, Science Advances, these engineered structures exhibit unique optical properties, including the ability to generate significant magnetism at optical frequencies. The heart of the invention is a tiny chip with a groundbreaking nanostructured surface on which blood is tested. (CREDIT: Will Kirk/Johns …