Glymphatic dysfunction linked to cognitive performance deficits in adults with ADHD, study finds
A new study published in the Journal of Affective Disorders has found that adults with attention-deficit/hyperactivity disorder (ADHD) show signs of glymphatic system dysfunction, which may be related to their cognitive difficulties. The findings suggest that disruptions in the brain’s waste clearance system could help explain some of the persistent memory and attention problems seen in adults with the condition. ADHD is a common neurodevelopmental disorder marked by symptoms of inattention, impulsivity, and hyperactivity. While it is often diagnosed in childhood, many people continue to experience symptoms well into adulthood. In adults, ADHD can interfere with work, relationships, and daily functioning, and is often accompanied by cognitive issues such as forgetfulness and difficulty sustaining focus. Although behavioral symptoms are widely studied, the biological mechanisms that underlie adult ADHD are less understood. One area of growing interest among scientists is the glymphatic system—a network that helps clear waste products from the brain. This system operates mainly during deep sleep and uses cerebrospinal fluid to flush out harmful substances. Problems with glymphatic function have been linked to …