Obesity reduces testosterone and sperm count by disrupting brain circuits
A recent study published in The Journal of Neuroscience sheds light on how obesity can disrupt reproductive health in males by altering brain circuitry. The research used mice fed a high-fat diet to mimic human obesity and found that it caused chronic changes in brain connections. These changes led to reduced testosterone, lower sperm count, and diminished libido in the mice. The study provides evidence that obesity weakens communication between the brain circuits that control both feeding and reproduction, potentially explaining the link between obesity and reproductive issues in men. The researchers were motivated to conduct this study because while it is well-known that obesity lowers testosterone in men, which impacts various functions like muscle mass, cognition, and reproductive health, the exact mechanisms by which obesity causes these changes are not fully understood. This knowledge gap is significant because obesity-related reproductive issues are becoming increasingly common. Obese men often suffer from low testosterone levels, reduced sperm count, and poor sperm quality. This study aimed to understand how chronic obesity alters brain circuitry to produce these …