I AM ALS, a group aimed at ending the degenerative nervous system disease, has paid tribute to Eric Dane, who died at the age of 53 Thursday.

The actor announced he was diagnosed with ALS last April and had worked with the advocacy group before his death.

“We are heartbroken by the passing of our friend @RealEricDane, a fierce advocate, a generous spirit, and a true champion in the movement to end ALS,” I AM ALS wrote on X.

Fans have poured into the comment section of an Instagram post announcing Eric Dane’s death. The actor died at 53 after battling ALS.

“I’m devastated. RIP, Eric,” one person wrote on a post by People.

Another commented: “So young. RIP McSteamy,” referring to his Grey’s Anatomy character’s nickname.

“I’m sitting here crying like a baby. He was such a lovely man, a family man. May he rest in peace,” a third said.

Dane leaves behind his wife of more than 20 years and their two daughters.

SAG-AFTRA, the world’s largest labor union representing performers and broadcasters, has paid tribute to Eric Dane’s following his death.

“We are heartbroken by the passing of Eric Dane, a #SagAftraMember since 1991,” the union wrote on X. “He inspired audiences and colleagues alike, and faced ALS with courage and a commitment to advocacy.”

Fellow Valentine’s Day actor Ashton Kutcher has paid tribute to Eric Dane following his death.

“The Franklin strip fanatics fantasy football league will miss Mr. Eric Dane. We know you’ll be watching from the booth. Miss you, buddy. Let’s keep fighting the fight to solve ALS,” Kutcher wrote on X.

Dane vowed that the condition would not stop him from acting. In Brilliant Minds, he played Matthew Ramati, a firefighter whose pride prevented him from revealing his own ALS diagnosis to his family.

Euphoria creator Sam Levinson has paid tribute to Eric Dane after the actor’s death.

“I’m heartbroken by the loss of our dear friend Eric,” Levinson told Variety. “Working with him was an honor. Being his friend was a gift. Eric’s family is in our prayers. May his memory be for a blessing.”

Dane played Cal Jacobs, a father hiding that he is gay, on Levinson’s hit drama. Dane died Thursday after battling ALS, a degenerative nervous system disease.

“With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS,” read the family’s statement to People. “He spent his final days surrounded by dear friends, his devoted wife, and his two beautiful daughters, Billie and Georgia, who were the center of his world.

“Throughout his journey with ALS, Eric became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight. He will be deeply missed, and lovingly remembered always. Eric adored his fans and is forever grateful for the outpouring of love and support he’s received. The family has asked for privacy as they navigate this impossible time.”

Eric Dane, known for his roles in hit TV shows Grey’s Anatomy and Euphoria, has died at age 53.

Dane revealed last April that he was diagnosed with ALS, a degenerative nervous system disease.

“He spent his final days surrounded by dear friends, his devoted wife, and his two beautiful daughters, Billie and Georgia, who were the center of his world,” his family said in a statement to People.