Scientists kill 192 million lab mice each year. Is there a better way?
Sign up for the Smarter Faster newsletter A weekly newsletter featuring the biggest ideas from the smartest people Notice: JavaScript is required for this content. Scientists stress out lab mice, a lot. Inducing chronic stress and anxiety in these furry critters is how scientists explore the bodily and cognitive effects of stress and discover anti-anxiety medications for humans. There are two primary ways researchers stress out a lab mouse: immobilization and restraint. As described in the Encyclopedia of Stress (Second Edition), immobilization involves “taping the four limbs of a rat or mouse to mounts secured to a metal frame using hypoallergenic tape. A pair of metal loops attached to the frame limits the range of motion of the animal’s head…The duration of a single episode of immobilization usually varies from 5 to 120 min or more. In addition, animals in chronic stress protocols may be immobilized each day for many weeks even months.” Psychologist Richard McCarty described the effects in the journal Psychoneuroendocrinology. “The struggling that is typical of the first several minutes of an …