This desert-roaming toad releases a compound with potential benefits similar to those from LSD and psilocybin Milan Zygmunt/Shutterstock A psychedelic compound secreted by a poisonous toad could help treat depression and anxiety, according to a study in mice. When frightened, Colorado river toads (Incilius alvarius) release a hallucinogenic compound related to the drug DMT from glands in their skin. DMT, or dimethyltryptamine, is similar in structure and effects to psilocybin, a hallucinogen found in “magic mushrooms”. Colorado river toads live in and around the Sonoran desert spanning parts of Arizona, California and Mexico, and people seeking out the groovy effects of the substance may either lick the toads directly, or extract the venom, dry it and smoke it. Researchers at Mount Sinai Hospital in New York investigated the potential health benefits of the toad secretions. We know that psychedelics like psilocybin can treat depression in some people, but it isn’t fully clear why this compound helps. However, it appears to interact with serotonin receptors and reset the activity of neural circuits in the brain. Most …