Scientists link immune system proteins to mental health conditions like schizophrenia and depression
New research suggests that immune system activity may play a role in the development of several major mental health conditions. The study, published in Molecular Psychiatry, identified 29 immune-related proteins that appear to contribute to the risk of disorders such as schizophrenia, depression, bipolar disorder, and Alzheimer’s disease. Many of these proteins are already being targeted by drugs used for other conditions, raising the possibility that treatments focused on the immune system could one day help people with psychiatric disorders. The researchers undertook this study to clarify whether immune system dysfunction actually causes mental health conditions or merely correlates with them. In recent years, many studies have found that people with depression, schizophrenia, and other disorders often have signs of increased inflammation. However, it has remained unclear whether this inflammation is a consequence of the illness, a contributing factor, or unrelated entirely. Resolving this uncertainty is essential for guiding the development of new therapies. To investigate this, the research team, led by Christina Dardani and Golam Khandaker at the University of Bristol, used a method …