All posts tagged: Pig

Patient Leaves Hospital as Transplanted Gene-Hacked Pig Organ Seems to Be Functioning Well

Patient Leaves Hospital as Transplanted Gene-Hacked Pig Organ Seems to Be Functioning Well

Image by Mass General Hospital/Michelle Rose Last month, surgeons at the Massachusetts General Hospital in Boston transplanted a kidney from a gene-hacked pig into a living 62-year-old man. The unusual procedure appears to have been a resounding success, with the patient being discharged from the hospital on Wednesday. The achievement could usher in a new era, potentially reducing our reliance on both hard-to-come-by human donor kidneys and the expensive dialysis machines that treat kidney disease and failure. The patient, Richard Slayman, had been struggling with kidney disease for over a decade. His previously transplanted human kidney had also shown signs of failure last year. But with his new kidney, which came from a genetically modified pig courtesy of biotech company eGenesis, Slayman is already doing much better. The organ is producing urine and removing waste from the blood, among other key functions, as the New York Times reports. “This moment — leaving the hospital today with one of the cleanest bills of health I’ve had in a long time — is one I wished would come …

Pig kidney transplant patient leaves Massachusetts hospital | US News

Pig kidney transplant patient leaves Massachusetts hospital | US News

The first patient to receive a kidney transplanted from a genetically modified pig has been discharged from hospital. Richard “Rick” Slayman received the organ in March in a world first after undergoing a four-hour surgery at the Massachusetts General Hospital (MGH) in Boston. The 62-year-old suffers from end-stage renal failure, a chronic disease where the kidneys can no longer function on their own. “This moment – leaving the hospital today with one of the cleanest bills of health I’ve had in a long time – is one I wished would come for many years,” he said in a statement on Wednesday. “Now, it’s a reality and one of the happiest moments of my life.” Image: Mr Slayman thanked well-wishers. Pic: Michelle Rose/Massachusetts General Hospital He thanked all the medical staff involved and who have cared for him – before and after – his “historic transplant”. He added: “I’m excited to resume spending time with my family, friends, and loved ones free from the burden of dialysis that has affected my quality of life for many …

Commentary: The first pig kidney has been transplanted into a living person. What does this mean for organ donation?

Commentary: The first pig kidney has been transplanted into a living person. What does this mean for organ donation?

FROM BIOTECH DREAM TO CLINICAL REALITY Only a few months ago, CRISPR gene editing made its debut in mainstream medicine. In November, drug regulators in the United Kingdom and US approved the world’s first CRISPR-based genome-editing therapy for human use – a treatment for life-threatening forms of sickle-cell disease. The treatment, known as Casgevy, uses CRISPR/Cas-9 to edit the patient’s own blood (bone-marrow) stem cells. By disrupting the unhealthy gene that gives red blood cells their “sickle” shape, the aim is to produce red blood cells with a healthy spherical shape. Although the treatment uses the patient’s own cells, the same underlying principle applies to recent clinical xenotransplants: Unsuitable cellular materials may be edited to make them therapeutically beneficial in the patient. Medicine and gene technology regulators are increasingly asked to approve new experimental trials using gene editing and CRISPR. However, neither xenotransplantation nor the therapeutic applications of this technology lead to changes to the genome that can be inherited. For this to occur, CRISPR edits would need to be applied to the cells at …

Surgeons complete first-ever gene-edited pig kidney transplant

Surgeons complete first-ever gene-edited pig kidney transplant

In a world first, surgeons at Massachusetts General Hospital successfully transplanted a genetically modified pig kidney into a person with chronic kidney disease. The historic procedure builds off of decades of research into gene editing of animal organs and could mark an inflection point in efforts to cut down on sometimes fatally lengthy transplant wait times. Recent advances in gene editing technology means procedures like these could become more common.  The patient, a 62-year-old man from Massachusetts named Richard Slayman, has severe diabetes and hypertension and has been on dialysis for seven years. He eventually received a new kidney from a human donor but it began showing signs of failure after five years. Slayman was on a waiting list for another kidney when his doctors suggested the possibility of receiving an experimental kidney from a gene-edited pig. “I saw [the transplant] not only as a way to help me, but a way to provide hope for the thousands of people who need a transplant to survive,” Slayman said in a statement.  The modified pig was …

A Gene-Edited Pig Kidney Was Just Transplanted Into a Person for the First Time

A Gene-Edited Pig Kidney Was Just Transplanted Into a Person for the First Time

Slayman received his first kidney transplant in 2018 from a human donor. The donor kidney initially functioned well, but Slayman started to go into kidney failure after years of living with diabetes. Diabetes is the leading cause of kidney disease, which can eventually result in kidney failure. He had no choice but to go on dialysis, a treatment that removes excess fluid and waste from a person’s blood. But the dialysis caused complications—his blood vessels were clotting and failing. Slayman wound up in the hospital regularly and endured dozens of procedures to try to fix the problem. “Slowly but surely, I witnessed my patient becoming increasingly despondent and depressed over his dialysis situation,” Winfred Williams, a kidney specialist and member of Slayman’s medical team, said on Thursday. Finally, Williams suggested a pig kidney transplant. Slayman agreed. “I saw it not only as a way to help me, but a way to provide hope for the thousands of people who need a transplant to survive,” Slayman said in a statement released by Massachusetts General Hospital. The …

Pig kidney transplanted into living human for the first time

Pig kidney transplanted into living human for the first time

The kidney transplant procedure is the first of its kind in a living person Michelle Rose/MASSACHUSETTS GENERAL HOSPITAL Surgeons have successfully transplanted a pig kidney into a 62-year-old man living with end-stage kidney disease. The recipient, Richard Slayman, is recovering well and is expected to be discharged from the hospital soon, mere days after the surgery. Is this the first ever pig kidney transplant? This is the first time a pig kidney has been transplanted into a living human, which makes it a significant milestone in the field of xenotransplantation, or the transfer of animal organs to humans. “The success of this transplant is the culmination of efforts by thousands of scientists and physicians over several decades,” said Tatsuo Kawai at Massachusetts General Hospital in a statement. “Our hope is that this transplant approach will offer a lifeline to millions of patients worldwide who are suffering from kidney failure.” Strictly speaking, however, this isn’t the first ever pig-to-human kidney transplant. The procedure has been performed five times in the past, all in people who were …

Patient Walking Around Hospital After Transplant of Gene-Hacked Pig Kidney

Patient Walking Around Hospital After Transplant of Gene-Hacked Pig Kidney

Image by Getty / Futurism In a world’s first, surgeons at the Massachusetts General Hospital in Boston have transplanted a kidney from a gene-hacked pig into a living 62-year-old man. Researchers are hoping the procedure could reduce our reliance on both hard-to-come-by human donor kidneys, and the expensive dialysis machines that treat kidney disease and failure. Fortunately, the surgeons’ efforts appear to have paid off — at least for now. The pig kidney started producing urine not long after the surgery last weekend, the New York Times reports. The patient’s condition also continues to improve, according to the report. In fact, he’s already walking the halls and could soon be discharged. It’s an especially important milestone, considering the patient, Richard “Rick” Slayman, is Black. Studies have shown that African-American patients have historically suffered from the highest rates of end-stage kidney disease. Xenotransplanted kidneys “could solve an intractable problem in the field — the inadequate access of minority patients to kidney transplants,” said Mass General associate chief of nephrology Winfred Williams in a statement. According to …

‘She’s a rude, belittling fat-shamer’: How Peppa Pig became every parent’s worst nightmare

‘She’s a rude, belittling fat-shamer’: How Peppa Pig became every parent’s worst nightmare

Stay ahead of the trend in fashion and beyond with our free weekly Lifestyle Edit newsletter Stay ahead of the trend in fashion and beyond with our free weekly Lifestyle Edit newsletter Reshmi Bennett, a bakery owner and children’s author, was not prepared to lose her battle with TV’s most divisive pig. Like so many youngsters, Bennett’s six-year-old son had been wooed by the porky charms of Peppa Pig, the anthropomorphic superstar of children’s animation. But once Bennett sat down to watch the programme with her little boy, she was horrified. “Peppa’s so dislikeable,” she tells me. “She’s rude, entitled and belittling. She’s also a sore loser and unsupportive of her friends. She fat-shames her dad and … [is] mean to her little brother.” Bennett says her son quickly grew out of watching Peppa after he was put on a (potentially healthier) diet of Paw Patrol and Numberblocks. But her concerns about the character aren’t hers alone. They echo one of the great debates currently defining modern parenthood: is Peppa Pig a force for good …

Chinese Scientists Implant First Pig Liver Into Brain-Dead Human

Chinese Scientists Implant First Pig Liver Into Brain-Dead Human

Who says nothing interesting ever happens in the world anymore? This week, in a “first of its kind” operation, a brain-dead human subject was implanted with the world’s first gene-edited pig liver transplant, according to SCMP.  In what could be a pioneering move, Chinese scientists have transplanted a gene-edited pig liver into a human, aiming to potentially mark a solution to organ shortages, the report says. The liver was modified to reduce rejection risks and was implanted into a brain-dead recipient, showing no rejection signs four days post-operation, as per the Air Force Medical University. SCMP writes that this procedure could significantly aid those with end-stage liver disease, possibly revolutionizing liver transplants.  Gene editing advancements in China also promise to enhance efficiency and accessibility in plant modification, reflecting broader strides in medical innovation, the report continues. SCMP notes that liver diseases annually claim 2 million lives globally, with China alone witnessing up to 500,000 new cases of liver failure yearly. Xenotransplantation, the process of transplanting organs across species, could be a hopeful strategy, especially for …

Calls for legal action after ‘unimaginable suffering’ filmed at Devon pig farm | Animal welfare

Calls for legal action after ‘unimaginable suffering’ filmed at Devon pig farm | Animal welfare

Undercover footage of pigs at a Devon farm showing them exposed to “unimaginable suffering” has prompted calls for legal action against the owners. The film crew said the video of pigs being kept in filthy, cramped conditions – featuring instances of cannibalism and malnourishment, as well as animals with untreated, bleeding wounds and hernias – was filmed at Cross Farm in Holsworthy, owned by WJ Watkins and Son. In one clip, a screaming pig was trampled on and bitten by her pen-mates and apparently died in front of the crew from Glass Wall Films. A spokesperson for WJ Watkins confirmed he was aware that covert filming took place on the farm in October, but declined to comment further, referring the Guardian instead to the National Pig Association (NPA). In one pen the pigs appear unable to move due to overcrowding. Photograph: Advocates for Animals On the basis of the footage, filmed across four non-consecutive nights, the solicitors firm Advocates for Animals has sent a letter of complaint to Heart of the South West trading standards …