Prenatal caffeine exposure and high-fat diet heighten risk of autism-like behaviors in rodents
Exposure to caffeine during pregnancy, combined with a high-fat diet after birth, significantly increases the risk of autism-like behaviors in rodents, according to new research published in Ecotoxicology and Environmental Safety. This increased risk is related to changes in gut bacteria and increased levels of a specific immune molecule, IL-17A. The findings shed light on the relationships between diet, prenatal environmental exposures, and neurodevelopmental disorders. The motivation behind this new study stems from a growing concern over the effects of prenatal caffeine exposure and high-fat diets on the developing brain. Previous research had already established a link between prenatal caffeine exposure and reduced fetal growth, with emerging evidence suggesting an increased risk of neurodevelopmental disorders like autism spectrum disorder (ASD). ASD is a complex developmental condition that involves persistent challenges in social interaction, speech and nonverbal communication, along with restricted and repetitive behaviors. Given the widespread consumption of caffeine and the prevalence of high-fat diets, understanding these potential risk factors is crucial for developing strategies to prevent ASD. “Most autism research focuses on genetic factors, …